98%Honokiol Magnolia bark extract 

Product: 98%Honokiol,Magnolia bark extract
Plantiginal: Magnolia officinalis
Parts used: Bark
Extracted method: Supercritical CO2 extraction
95%Honokiol Properties effects:
1.Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, 
leukemia, bladder, lung, prostate, colon cancer cell lines. Honokiol 
inhibits phosphorylation of Akt, p44/42 mitogen-activated protein kinase 
(MAPK), src. Additionally, honokiol modulates the nuclear factkappa B 
(NF-B) activation pathway, an upstream effectof vascular endothelial growth 
fact(VEGF), cyclooxygenase 2 (COX-2), MCL1, all significant pro-
angiogenic survival factors. Honokiol induces caspase-dependent apoptosis 
in a TRAIL-mediated manner, potentiates the pro-apoptotic effects of 
doxorubicin other etoposides. So potent is honokiol's pro-apoptotic effects 
that it overcomes even notoriously drug resistant neoplasms such as multiple 
myelomaonic B-cell leukemia.
2. Honokiol has been shown to promote outgrowth have effects in cortical . 
Additionally, honokiol increases free cytoplasmic in rat cortical neurons.
3. Honokiol inhibits platelet aggregation in rabbits in a dose-dependent 
manner, protects cultured RAEC against oxidized low density injury. 
Honokiol significantly increases the metabolite , potentially the key factin 
honokiol's anti-thrombotic activity.